HRID1798508

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID61534230

未命名化合物

2 次

结构：Cc1cccc(-c2cc(-c3cncc(-c4ccc(C(=O)N5CCN(C(C)C)CC5)cc4)c3)cc(O)n2)n1

HCID178424464

未命名化合物

PRODUCTS

生成物

结构：Cc1cccc(-c2cc(-c3cncc(-c4ccc(CN5CCN(C(C)C)CC5)cc4)c3)cc(O)n2)n1

HCID178424463

未命名化合物

PROCEDURE

实验过程

is prepared analogously to [4-(6′-Hydroxy-6-methyl-[2,2′;4′,3″]terpyridin-5″-yl)-phenyl]-(4-isopropyl-piperazin-1-yl)-methanone (Example 2.109) by replacing (4-isopropyl-piperazin-1-yl)-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanone with 4-(4-Isopropyl-piperazin-1-ylmethyl)-phenyl boronic acid (Intermediate B3).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-62cd4cc26d654666bbf168ec550396a5
来源数据集: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08343966B2
来源说明: uspto-grants-2013_01

反应 SMILES

[OH:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[N:9]=2)[CH:5]=[C:4]([C:15]2[CH:16]=[N:17][CH:18]=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([C:27]([N:29]4[CH2:34][CH2:33][N:32]([CH:35]([CH3:37])[CH3:36])[CH2:31][CH2:30]4)=O)=[CH:23][CH:22]=3)[CH:20]=2)[CH:3]=1.C(N1CCN(CC2C=CC(B(O)O)=CC=2)CC1)(C)C>>[CH:35]([N:32]1[CH2:31][CH2:30][N:29]([CH2:27][C:24]2[CH:23]=[CH:22][C:21]([C:19]3[CH:20]=[C:15]([C:4]4[CH:3]=[C:2]([OH:1])[N:7]=[C:6]([C:8]5[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[N:9]=5)[CH:5]=4)[CH:16]=[N:17][CH:18]=3)=[CH:26][CH:25]=2)[CH2:34][CH2:33]1)([CH3:37])[CH3:36]