(5''-Bromo-[2,2';4',3'']terpyridin-6'-yl)-cyclopropyl-amine → Cyclopropyl-{5''-[3-(4-isopropyl-piperazin-1-yl)-prop-1-ynyl]-[2,2';4',3'']terpyridin-6'-yl}-amine

Participants

Role	Name	HCID	Charge
Reactant	(5''-Bromo-[2,2';4',3'']terpyridin-6'-yl)-cyclopropyl-amine	HCID 44135953	—
Reactant	1-(Prop-2-YN-1-YL)-4-(propan-2-YL)piperazine	HCID 58366557	—
Reactant	Methyl-[5''-(3-methyl-3H-imidazol-4-ylethynyl)-[2,2';4',3'']terpyridin-6'-yl]-amine	HCID 86633650	—
Product	Cyclopropyl-{5''-[3-(4-isopropyl-piperazin-1-yl)-prop-1-ynyl]-[2,2';4',3'']terpyridin-6'-yl}-amine	HCID 68760033	—

Reaction Steps

is prepared analogously to Methyl-[5″-(3-methyl-3H-imidazol-4-ylethynyl)-[2,2′;4′,3″]terpyridin-6′-yl]-amine (Example 2.182) by replacing (5″-Bromo-[2,2′;4′,3″]terpyridin-6′-yl)-methyl-amine (Example 2.1; step1) with (5″-Bromo-[2,2′;4′,3″]terpyridin-6′-yl)-cyclopropyl-amine (Example 1.26) and by replacing 1-methyl-5-((trimethylsilyl)ethynyl)-1H-imidazole with 1-isopropyl-4-(prop-2-ynyl)piperazine (Intermediate D1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08343966B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-0d12044fee30428ba60b3d4423e0e3c3
Source note	uspto-grants-2013_01