Trimethylsilylacetylene → Cyclopropyl-(5''-trimethylsilanylethynyl-[2,2';4',3'']terpyridin-6'-yl)-amine

Participants

Role	Name	HCID	Charge
Reactant	Trimethylsilylacetylene	HCID 66111	—
Reactant	(5''-Bromo-[2,2';4',3'']terpyridin-6'-yl)-cyclopropyl-amine	HCID 44135953	—
Reactant	Methyl-[5''-(3-methyl-3H-imidazol-4-ylethynyl)-[2,2';4',3'']terpyridin-6'-yl]-amine	HCID 86633650	—
Product	Cyclopropyl-(5''-trimethylsilanylethynyl-[2,2';4',3'']terpyridin-6'-yl)-amine	HCID 68947114	—

Reaction Steps

is prepared analogously to Methyl-[5″-(3-methyl-3H-imidazol-4-ylethynyl)-[2,2′;4′,3″]terpyridin-6′-yl]-amine (Example 2.182) by replacing (5″-Bromo-[2,2′;4′,3″]terpyridin-6′-yl)-methyl-amine (Example 2.1; step 1) with (5″-Bromo-[2,2′;4′,3″]terpyridin-6′-yl)-cyclopropyl-amine (Example 1.26) and by replacing 1-methyl-5-((trimethylsilyl)ethynyl)-1H-imidazole with ethynyl-trimethyl-silane to afford the title compound; [M+H]+ 385.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08343966B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-f7503e2d0ad344feb35e2912bd5df538
Source note	uspto-grants-2013_01