[4-(6'-Methylamino-[2,2';4',3'']terpyridin-5''-yl)-phenyl]-(4-methyl-piperazin-1-yl)-methanone → 5''-[4-(4-Isopropyl-piperazin-1-ylmethyl)-phenyl]-6'-pyrrolidin-1-yl-[2,2';4',3'']terpyridine

Participants

Reaction Steps

is prepared analogously to [4-(6′-Methylamino-[2,2′;4′,3″]terpyridin-5″-yl)-phenyl]-(4-methyl-piperazin-1-yl)-methanone (Example 2.1) by replacing (5″-Bromo-[2,2′;4′,3″]terpyridin-6′-yl)-methyl-amine (Example 2.1, step1) with 5″-Bromo-6′-pyrrolidin-1-yl-[2,2′;4′,3″]terpyridine and by replacing (4-Methyl-piperazin-1-yl)-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanone with 4-(4-Isopropyl-piperazin-1-ylmethyl)-phenyl boronic acid (Intermediate B3).

Provenance & Evidence