[4-(6'-Amino-[2,2';4',3'']terpyridin-5''-yl)-phenyl]-piperazin-1-yl-methanone → 5''-[3-(4-Isopropyl-piperazin-1-ylmethyl)-phenyl]-[2,2';4',3'']terpyridin-6'-ylamine
Reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[CH:5]=[C:4]([C:14]2[CH:15]=[N:16][CH:17]=[C:18](C3C=CC(C(N4CCNCC4)=O)=CC=3)[CH:19]=2)[CH:3]=1.[CH:34]([N:37]1[CH2:42][CH2:41][N:40]([CH2:43][C:44]2[CH:45]=[C:46](B(O)O)[CH:47]=[CH:48][CH:49]=2)[CH2:39][CH2:38]1)([CH3:36])[CH3:35]>>[CH:34]([N:37]1[CH2:38][CH2:39][N:40]([CH2:43][C:44]2[CH:49]=[C:48]([C:18]3[CH:19]=[C:14]([C:4]4[CH:3]=[C:2]([NH2:1])[N:7]=[C:6]([C:8]5[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=5)[CH:5]=4)[CH:15]=[N:16][CH:17]=3)[CH:47]=[CH:46][CH:45]=2)[CH2:41][CH2:42]1)([CH3:36])[CH3:35]Participants
3
Procedure
This compound is prepared analogously to [4-(6′-Amino-[2,2′;4′,3″]terpyridin-5″-yl)-phenyl]-piperazin-1-yl-methanone (Example 2.50) by replacing piperazin-1-yl-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanone with 3-((4-isopropylpiperazin-1-yl)methyl)phenylboronic acid (Intermediate B14).
Sources & evidence
- ORD record
- ord-9dfb962f63ed4e7285250847c7242a0e
- Source dataset
- uspto-grants-2013_01
- Patent number
- US08343966B2
Reaction notes
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