HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl)piperazine → 5''-(3-Aminomethyl-5-methyl-phenyl)-[2,2';4',3'']terpyridin-6'-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl)piperazine | HCID 17749913 | — |
| Reactant | [4-(6'-Amino-[2,2';4',3'']terpyridin-5''-yl)-phenyl]-piperazin-1-yl-methanone | HCID 44137101 | — |
| Reactant | 3-Aminomethyl-5-methyl-phenyl boronic acid | HCID 86633649 | — |
| Product | 5''-(3-Aminomethyl-5-methyl-phenyl)-[2,2';4',3'']terpyridin-6'-ylamine | HCID 68735265 | — |
Reaction Steps
This compound is prepared analogously to [4-(6′-Amino-[2,2′;4′,3″]terpyridin-5″-yl)-phenyl]-piperazin-1-yl-methanone (Example 2.50) by replacing piperazin-1-yl-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanone with 5″-(3-Aminomethyl-5-methyl-phenyl boronic acid (Intermediate B27).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08343966B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-eae63a1f715749e19292d3e200fdc41b |
| Source note | uspto-grants-2013_01 |