4-[4-(4,4,5-Trimethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-piperazine-1-carboxylic acid tert-butyl ester → 4-[4-(6'-Amino-[2,2';4',3'']terpyridin-5''-yl)-benzyl]-piperazine-1-carboxylic acid tert-butyl ester

Participants

Role	Name	HCID	Charge
Reactant	4-[4-(4,4,5-Trimethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-piperazine-1-carboxylic acid tert-butyl ester	HCID 68757846	—
Reactant	5''-[1-(Tetrahydro-pyran-4-yl)-1H-pyrazol-4-yl]-[2,2';4',3'']terpyridin-6'-ylamine	HCID 68761382	—
Product	4-[4-(6'-Amino-[2,2';4',3'']terpyridin-5''-yl)-benzyl]-piperazine-1-carboxylic acid tert-butyl ester	HCID 68759293	—

Reaction Steps

This compound is prepared analogously to 5″-[1-(Tetrahydro-pyran-4-yl)-1H-pyrazol-4-yl]-[2,2′;4′,3″]terpyridin-6′-ylamine (Example 2.156) by replacing 1-(tetrahydro-pyran-4-yl)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (Intermediate B18) with 4-[4-(4,4,5-trimethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-piperazine-1-carboxylic acid tert-butyl ester.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08343966B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-543dd69b1f2641be9e21f2266b9eb946
Source note	uspto-grants-2013_01