5''-Bromo-[2,2';4',3'']terpyridin-6'-ylamine → 5''-(1-Piperidin-4-yl-1H-pyrazol-4-yl)-[2,2';4',3'']terpyridin-6'-ylamine

HRID 1798535Notes

Reaction equation

HRID 1798535 reaction equation
C[NH:2][C:3]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[CH:6]=[C:5]([C:15]2[CH:16]=[N:17][CH:18]=[C:19]([C:21]3[CH:22]=[N:23][N:24]([CH:26]4[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]4)[CH:25]=3)[CH:20]=2)[CH:4]=1.BrC1C=C(C2C=C(N)N=C(C3C=CC=CN=3)C=2)C=NC=1>>[NH:29]1[CH2:28][CH2:27][CH:26]([N:24]2[CH:25]=[C:21]([C:19]3[CH:20]=[C:15]([C:5]4[CH:4]=[C:3]([NH2:2])[N:8]=[C:7]([C:9]5[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=5)[CH:6]=4)[CH:16]=[N:17][CH:18]=3)[CH:22]=[N:23]2)[CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 441360785''-Bromo-[2,2';4',3'']terpyridin-6'-ylamineHCID 68757252Methyl-[5''-(1-piperidin-4-yl-1H-pyrazol-4-yl)-[2,2';4',3'']terpyridin-6'-yl]-amine

Product 1

HCID 687587475''-(1-Piperidin-4-yl-1H-pyrazol-4-yl)-[2,2';4',3'']terpyridin-6'-ylamine

Procedure

This compound is prepared analogously to methyl-[5″-(1-piperidin-4-yl-1H-pyrazol-4-yl)-[2,2′;4′,3″]terpyridin-6′-yl]-amine (Example 2.183) by replacing (5″-Bromo-[2,2′;4′,3″]terpyridin-6′-yl)-methyl-amine (Example 2.1; step1) with 5″-Bromo-[2,2′;4′,3″]terpyridin-6′-ylamine (Example 1.31).

Sources & evidence

ORD record
ord-bedac4cd2aed4dbca0419a72a517bad4
Source dataset
uspto-grants-2013_01
Patent number
US08343966B2

Reaction notes

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