5''-Bromo-[2,2';4',3'']terpyridin-6'-ylamine → 5''-[1-(1-Isopropyl-piperidin-4-yl)-1H-pyrazol-4-yl]-[2,2';4',3'']terpyridin-6'-ylamine
Reaction equation
[CH:1]([N:4]1[CH2:9][CH2:8][CH:7]([N:10]2[CH:14]=[C:13]([C:15]3[CH:16]=[C:17]([C:21]4[CH:26]=[C:25]([NH:27]C)[N:24]=[C:23]([C:29]5[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=5)[CH:22]=4)[CH:18]=[N:19][CH:20]=3)[CH:12]=[N:11]2)[CH2:6][CH2:5]1)([CH3:3])[CH3:2].BrC1C=C(C2C=C(N)N=C(C3C=CC=CN=3)C=2)C=NC=1>>[CH:1]([N:4]1[CH2:9][CH2:8][CH:7]([N:10]2[CH:14]=[C:13]([C:15]3[CH:16]=[C:17]([C:21]4[CH:26]=[C:25]([NH2:27])[N:24]=[C:23]([C:29]5[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=5)[CH:22]=4)[CH:18]=[N:19][CH:20]=3)[CH:12]=[N:11]2)[CH2:6][CH2:5]1)([CH3:3])[CH3:2]Participants
3
Procedure
This compound is prepared analogously to {5″-[1-(1-Isopropyl-piperidin-4-yl)-1H-pyrazol-4-yl]-[2,2′;4′,3″]terpyridin-6′-yl}-methyl-amine (Example 2.175) by replacing (5″-Bromo-[2,2′;4′,3″]terpyridin-6′-yl)-methyl-amine (Example 2.1; step1) with 5″-Bromo-[2,2′;4′,3″]terpyridin-6′-ylamine (Example 1.31).
Sources & evidence
- ORD record
- ord-f6b5ceaf52814121a0a8f13ecd07f7e3
- Source dataset
- uspto-grants-2013_01
- Patent number
- US08343966B2
Reaction notes
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