Methyl-[5''-(1-piperidin-4-yl-1H-pyrazol-4-yl)-[2,2';4',3'']terpyridin-6'-yl]-amine → Methyl-[6'-(1-methyl-1H-pyrazol-3-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-[3,4']bipyridinyl-2'-yl]-amine

HRID 1798539Notes

Reaction equation

HRID 1798539 reaction equation
[CH3:1][NH:2][C:3]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13]C=C[N:10]=2)[CH:6]=[C:5]([C:15]2[CH:16]=[N:17][CH:18]=[C:19]([C:21]3[CH:22]=[N:23][N:24]([CH:26]4[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]4)[CH:25]=3)[CH:20]=2)[CH:4]=1.BrC1C=C(C2C=C(C3C=CN(C)N=3)N=C(NC)C=2)[CH:36]=[N:37]C=1>>[CH3:1][NH:2][C:3]1[CH:4]=[C:5]([C:15]2[CH:16]=[N:17][CH:18]=[C:19]([C:21]3[CH:22]=[N:23][N:24]([CH:26]4[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]4)[CH:25]=3)[CH:20]=2)[CH:6]=[C:7]([C:9]2[CH:14]=[CH:13][N:37]([CH3:36])[N:10]=2)[N:8]=1

Participants

3

Reactant 2

HCID 68757252Methyl-[5''-(1-piperidin-4-yl-1H-pyrazol-4-yl)-[2,2';4',3'']terpyridin-6'-yl]-amineHCID 68759433[5-Bromo-6'-(1-methyl-1H-pyrazol-3-yl)-[3,4']bipyridinyl-2'-yl]-methyl-amine

Product 1

HCID 44123670Methyl-[6'-(1-methyl-1H-pyrazol-3-yl)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-[3,4']bipyridinyl-2'-yl]-amine

Procedure

This compound is prepared analogously to Methyl-[5″-(1-piperidin-4-yl-1H-pyrazol-4-yl)-[2,2′;4′,3″]terpyridin-6′-yl]-amine (Example 2.183) by replacing (5″-Bromo-[2,2′;4′,3″]terpyridin-6′-yl)-methyl-amine (Example 2.1; step1) by [5-Bromo-6′-(1-methyl-1H-pyrazol-3-yl)-[3,4′]bipyridinyl-2′-yl]-methyl-amine (Example 2.178, step 1).

Sources & evidence

ORD record
ord-66dd079a71a14025842fcfe05ab62d06
Source dataset
uspto-grants-2013_01
Patent number
US08343966B2

Reaction notes

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