反应详情

To a suspension of cesium carbonate (1 eq, 0.78 mmol, 0.254 g) in acetone (3 ml) is added 3-bromoprop-1-yne (80% in toluene) (1 eq, 0.78 mmol, 0.1 g) followed by 1-isopropylpiperazine (1 eq, 0.78 mmol, 0.073 ml). The reaction mixture is stirred for 4 hours at room temperature. The resulting suspension is filtered and the filtrate evaporated to afford the title compound; [M+H]+ 167.

1. filtrationThe resulting suspension is filtered
2. customthe filtrate evaporated