Propargyl bromide → 1-(Prop-2-YN-1-YL)-4-(propan-2-YL)piperazine

HRID 1798554Notes

Reaction equation

HRID 1798554 reaction equation
C(=O)([O-])[O-].[Cs+].[Cs+].Br[CH2:8][C:9]#[CH:10].[CH:11]([N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1)([CH3:13])[CH3:12]>CC(C)=O>[CH:11]([N:14]1[CH2:19][CH2:18][N:17]([CH2:10][C:9]#[CH:8])[CH2:16][CH2:15]1)([CH3:13])[CH3:12]

Participants

5

Reactant 3

HCID 7842Propargyl bromideHCID 10796Cesium carbonateHCID 780131-Isopropylpiperazine

Product 1

HCID 583665571-(Prop-2-YN-1-YL)-4-(propan-2-YL)piperazine

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a suspension of cesium carbonate (1 eq, 0.78 mmol, 0.254 g) in acetone (3 ml) is added 3-bromoprop-1-yne (80% in toluene) (1 eq, 0.78 mmol, 0.1 g) followed by 1-isopropylpiperazine (1 eq, 0.78 mmol, 0.073 ml). The reaction mixture is stirred for 4 hours at room temperature. The resulting suspension is filtered and the filtrate evaporated to afford the title compound; [M+H]+ 167.

Workup

  1. filtrationThe resulting suspension is filtered
  2. customthe filtrate evaporated

Sources & evidence

ORD record
ord-5de146edc0a14fbfbfbfb595ae4db975
Source dataset
uspto-grants-2013_01
Patent number
US08343966B2

Reaction notes

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