HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(3,5-Dimethoxy-4-methylphenyl)furan → 1-(5-(3,5-Dimethoxy-4-methylphenyl)furan-2-yl)-2-methoxy-2-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(3,5-Dimethoxy-4-methylphenyl)furan | HCID 58432024 | — |
| Reactant | N,2-dimethoxy-N-methyl-2-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)acetamide | HCID 58432086 | — |
| Product | 1-(5-(3,5-Dimethoxy-4-methylphenyl)furan-2-yl)-2-methoxy-2-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)ethanone | HCID 58432011 | 29% |
Reaction Steps
N,2-Dimethoxy-N-methyl-2-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)acetamide was reacted with 2-(3,5-dimethoxy-4-methylphenyl)furan according to the procedure used for the synthesis of Example 12. Purification by chromatography (EtOAc-hexanes) gave 1-(5-(3,5-dimethoxy-4-methylphenyl)furan-2-yl)-2-methoxy-2-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)ethanone as a yellow foam (0.148 g, 29% yield). MS: m/z 449.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08343970B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-5d0e068221bf4846bdb2c665af85d382 |
| Source note | uspto-grants-2013_01 |