HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Tert-butyldimethylsilyloxy)methylbenzhydrazide → 2-(4-(((Tert-butyldimethylsilyl)oxy)methyl)phenyl)-5-cyclopropyl-1,3,4-oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Tert-butyldimethylsilyloxy)methylbenzhydrazide | HCID 10707914 | — |
| Reactant | Ethyl cyclopropanecarboximidate hydrochloride | HCID 20026660 | — |
| Product | 2-(4-(((Tert-butyldimethylsilyl)oxy)methyl)phenyl)-5-cyclopropyl-1,3,4-oxadiazole | HCID 58432005 | 40% |
Reaction Steps
4-(((Tert-butyldimethylsilyl)oxy)methyl)benzohydrazide was reacted with ethyl cyclopropanecarbimidate hydrochloride according to the procedure used for the synthesis of Example 18. Purification by chromatography (EtOAc-hexanes) gave 2-(4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)-5-cyclopropyl-1,3,4-oxadiazole as a brown oil (3.7 g, 40% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08343970B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-d0670a1bc12a4353aa35864724de55a4 |
| Source note | uspto-grants-2013_01 |