Methyl (2E)-3-{3-fluoro-2-[(triphenylphosphoranylidene)amino]phenyl}propenoate → Methyl [8-fluoro-3-(2-methoxy-5-trifluoromethylphenyl)-2-(9-methoxy-3,4-dihydro-1H-pyrazino[1,2-a]indol-2-yl)-3,4-dihydroquinazolin-4-yl]acetate

Participants

Reaction Steps

Starting with 500 mg (1.1 mmol) of the iminophosphorane from Example 12A, 238 mg (1.1 mmol) of 2-isocyanato-1-methoxy-4-(trifluoromethyl)benzene and 222 mg (1.1 mmol) of 9-methoxy-1,2,3,4-tetrahydropyrazino[1,2-a]indole from Example 34A, the general procedure [M] gives 270 mg (38% of theory) of product.

Provenance & Evidence