HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethyl)phenyl isocyanate → Methyl {8-fluoro-2-(7-methoxy-3,4-dihydropyrazino[1,2-a]indol-2-yl)-3-[3-(tri-fluoromethyl)phenyl]-3,4-dihydroquinazolin-4-yl}acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethyl)phenyl isocyanate | HCID 9483 | — |
| Reactant | Methyl (2E)-3-{3-fluoro-2-[(triphenylphosphoranylidene)amino]phenyl}propenoate | HCID 11983908 | — |
| Reactant | 7-Methoxy-1,2,3,4-tetrahydropyrazino[1,2-a]indole | HCID 44264336 | — |
| Product | Methyl {8-fluoro-2-(7-methoxy-3,4-dihydropyrazino[1,2-a]indol-2-yl)-3-[3-(tri-fluoromethyl)phenyl]-3,4-dihydroquinazolin-4-yl}acetate | HCID 58941056 | — |
Reaction Steps
Starting with 182 mg (0.4 mmol) of the iminophosphorane from Example 12A, 134 mg (0.4 mmol) of 1-isocyanato-3-(trifluoromethyl)benzene and 81 mg (0.4 mmol) of 7-methoxy-1,2,3,4-tetrahydropyrazino[1,2-a]indole from Example 35A, the general procedure [M] gives 140 mg (62% of theory) of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08343981B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-fb6fbb77bf96445f86ef7f14396aa9ee |
| Source note | uspto-grants-2013_01 |