Dichloromethane → 4-Chloroquinazoline

Participants

Reaction Conditions

Reaction Steps

To a solution of the quinazoline 2 (0.168 g, 0.29 mmol) in DCM (1.5 mL) was added TMSBr (0.079 mL, 0.61 mmol) at 0° C. The reaction was stirred for 1 h at 0° C., then for 1 h at RT. The reaction was quenched with water (3 mL) and stirred for 15 min. The aqueous layer was washed with EtOAc (5 mL), and dried with lyophilizer overnight to give desired product 3 as white foam (0.14 g. 100% yield). LC/MS (10-99%) M/Z 406.0 retention time 3.32 min.

Provenance & Evidence