反应详情

1-[3-(benzyloxy)phenyl]-1H-1,2,4-triazole (250 mg, 0.995 mmol) was dissolved in 5 mL methanol. The solution was degassed and backfilled with nitrogen. Palladium on carbon (10% w/w, 106 mg, 0.1 mmol) was then added. The reaction vessel was degassed and backfilled with hydrogen 3 times and stirred under a hydrogen balloon at room temperature. The reaction was stirred overnight. It was then diluted with 5 mL acetone and filtered through a plug of silica gel (5 g), which was washed thoroughly with acetone. Concentration afforded the product as white solid. LRMS calc: 161.1; obs: 162.2 (M+1).

1. customThe solution was degassed
2. customThe reaction vessel was degassed
3. stirringThe reaction was stirred overnight
4. additionIt was then diluted with 5 mL acetone
5. filtrationfiltered through a plug of silica gel (5 g), which
6. washwas washed thoroughly with acetone
7. concentrationConcentration