反应详情

N′,4-Dihydroxybenzenecarboximidamide (1.28 g, 8.4 mmol) was suspended in 3 mL ethanol and 3 mL trimethylorthoformate in a 20 mL biotage microwave reaction tube. The mixture was sealed and microwaved at 150° C. for 10 min. The solvent was removed by concentration and the residue was purified by column chromatography eluting with 20% DCM/hexanes to give the desired product as white solid. LRMS calc: 162.0; obs: 163.2 (M+1).

1. customThe mixture was sealed
2. custommicrowaved at 150° C. for 10 min
3. customThe solvent was removed by concentration
4. customthe residue was purified by column chromatography
5. washeluting with 20% DCM/hexanes