Hydrazine → 4-(4-methoxyphenyl)-1H-pyrazole

HRID 1798811Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1798811
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH:12]=O)[CH:10]=O)=[CH:5][CH:4]=1.[NH2:14][NH2:15]>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:12]=[N:14][NH:15][CH:10]=2)=[CH:5][CH:4]=1

Komponenten

4

Edukt 2

HCID 9321HydrazineHCID 38493702-(4-Methoxyphenyl)malondialdehyde

Produkt 1

HCID 35967514-(4-methoxyphenyl)-1H-pyrazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

The (4-methoxyphenyl)malonaldehyde (1.5 g, 8.42 mmol) was dissolved in ethanol (10 mL), followed by addition of hydrazine (540 mg g, 16.8 mmol). The pale yellow solution was heated in a microwave sealed tube at 110° C. overnight. Large amount of white crystalline solid formed. The reaction mixture was cooled to 0° C. The white solid was collected by filtration and was washed with 5 mL of ice-cold ethanol to give the desired product, which was further dried under high vacuum pump.

Aufarbeitung

  1. temperatureThe pale yellow solution was heated in a microwave
  2. customsealed tube at 110° C. overnight
  3. customLarge amount of white crystalline solid formed
  4. filtrationThe white solid was collected by filtration
  5. washwas washed with 5 mL of ice-cold ethanol

Quellen und Nachweise

ORD-Eintrag
ord-e03ad4cccc694b3abd69acd3f6ef6eaf
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08343990B2

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