2-Chloro-4,5-dimethylpyrimidine → 2-{2-[1-(4,5-Dimethylpyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethanol

Participants

Reaction Conditions

Reaction Steps

The titled compound was prepared from 2-chloro-4,5-dimethylpyrimidine and rac cis-tert-Butyl 4-[2-(2-hydroxyethyl)cyclopropyl]piperidine-1-carboxylate by a procedure analogous to that described in Example 6, step 2, with the exception of reaction temperature and time. The reaction was heated at 90° C. for 2 h.

Provenance & Evidence