HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1798833Generated: November 3, 2026
2-Chloro-5-fluoro-4-methylpyrimidine → 2-{2-[1-(5-Fluoro-4-methylpyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethanol
https://huagongshe.com/reaction/1798833
Participants
| Role | Name | HCID | Charge |
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| Reactant | 2-Chloro-5-fluoro-4-methylpyrimidine | HCID 20778073 | — |
| Reactant | Cis tert-butyl 4-[2-(2-hydroxyethyl)cyclopropyl]piperidine-1-carboxylate | HCID 66935269 | — |
| Product | 2-{2-[1-(5-Fluoro-4-methylpyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethanol | HCID 58128560 | — |
Reaction Steps
The titled compound was prepared from 2-chloro-5-fluoro-4-methylpyrimidine and rac cis-tert-Butyl-4-[-2-(2-hydroxyethyl)cyclopropyl]piperidine-1-carboxylate by a procedure analogous to example 6 step 2, with the exception of reaction temperature. The reaction was heated at 90° C. for 2 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08343990B2 |
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| Source dataset | uspto-grants-2013_01 |
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| ORD ID | ord-4495146233c249cabe34a17605046948 |
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| Source note | uspto-grants-2013_01 |
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