HCID 58128488, compound → HCID 123588455, compound

HRID 1798834Notes

Reaction equation

HRID 1798834 reaction equation
[OH:1][CH2:2][CH2:3][CH:4]1[CH2:6][CH:5]1[CH:7]1[CH2:12][CH2:11][N:10]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:9][CH2:8]1.[F:20][C:21]1[CH:22]=[C:23](O)[CH:24]=[CH:25][C:26]=1[C:27]1[O:28][C:29]([CH3:32])=[N:30][N:31]=1>>[F:20][C:21]1[CH:22]=[C:23]([CH:24]=[CH:25][C:26]=1[C:27]1[O:28][C:29]([CH3:32])=[N:30][N:31]=1)[O:1][CH2:2][CH2:3][C@H:4]1[CH2:6][C@H:5]1[CH:7]1[CH2:12][CH2:11][N:10]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:9][CH2:8]1

Participants

3

Reactant 2

HCID 58128488HCID 58128488, compoundHCID 136109960HCID 136109960, compound

Product 1

HCID 123588455HCID 123588455, compound

Procedure

The title compound was synthesized using rac-tert-butyl 4-[2-(2-hydroxyethyl)cyclopropyl]piperidine-1-carboxylate from Example 1 and 3-fluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenol through a Mitsunobu reaction by a procedure analogous to that procedure reported for Example 6, step 3.

Workup

  1. customthrough a Mitsunobu reaction by a procedure analogous to that procedure

Sources & evidence

ORD record
ord-06d7f7cbb23c4ad898c731195536ac65
Source dataset
uspto-grants-2013_01
Patent number
US08343990B2

Reaction notes

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