Dimethyl Sulfoxide → HCID 59506362, compound

Participants

Reaction Steps

To a solution of 1-benzyl-6-(4-methoxybenzyl)-4-(methylthio)-1,6,7,8-tetrahydro-1,2,3,5,6-pentaazaacenaphthylene (2.00 g, 4.79 mmol) in dichloromethane (40 mL) was added MCPBA (3.62 g, 50%, 10.53 mmol) and the mixture was stirred overnight. DMSO (5 mL) was added and the mixture was stirred for 10 min to quench the reaction. Saturated aqueous NaHCO3 (150 mL) and dichloromethane (250 mL) was added and the mixture was stirred for 1-2 h. dichloromethane layer was separated and washed with aqueous NaCl (3×150 mL), dried over Na2SO4, Filtered and concentrated to give the crude product as a brown solid (1.66 g, 77%). The crude product was used for next step directly without further purification. LC-Mass (m/e): 450.52 (M+1).

Provenance & Evidence