Sodium Carbonate → HCID 59543413, compound

Participants

Reaction Conditions

Reaction Steps

5-Bromo-3′,4′,5′,6′-tetrahydro-2′H-[2,4′]bipyridinyl-1-carboxylic acid tert-butyl ester (0.6 g, 1.8 mmol), 4-morpholinylphenylboronic acid (400 mg, 1.9 mmol), bis(triphenylphosphine)-palladium(II)chloride (0.06 g, 0.09 mmol), 1 M Na2CO3 (4 ml) and acetonitrile (4 ml) were mixed in a 5 mL microwave vial. The reaction mixture was heated 1500 sec at 85° C. The water layer was removed. The acetonitrile phase was filtered and evaporated. The remainder was purified on a silicagel column with heptane: EtOAc (1:1) as eluent. 730 mg (98%) was isolated as the free base.

Provenance & Evidence