Water → HCID 59543403, compound

Participants

Reaction Steps

5-(4-Morpholin-4-ylphenyl)-3′,4′,5′,6′-tetrahydro-2′H-[2,4′]bipyridinyl-1′-carboxylic acid tert-butyl ester (0.37 g, 0.874 mmol) was dissolved in DCM (12 mL), TFA (4 mL) was added and the reaction mixture was stirred at RT for 1 hour, until all starting material had disappeared. Water and 1 N NaOH was added until pH=12. After extraction with DCM (4×40 mL) the DCM phase was dried with Na2CO3, filtered and evaporated to give 280 mg (100%) white crystals.

Provenance & Evidence