Phosphorus oxychloride → HCID 131730134, compound

Participants

Reaction Conditions

Reaction Steps

6-(1-Isopropylpiperidin-4-yl)pyridazin-3-on (5.76 g, 26 mmol) was added to POCl3 (50 mL) and the reaction mixture was heated for 2 hours at 60° C. The excess of POCl3 was evaporated in vacuo and ethanol (96%) was added under an exothermic reaction. The reaction mixture was cooled and a precipitate was obtained. The product was filtered off after drying in vacuo and 6.34 g (88%) white crystals were isolated.

Provenance & Evidence