HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylpyridine-4-boronic acid → 5-(4-Isopropylpiperazin-1-ylmethyl)-2'-methyl-[2,4']bipyridinyl, trihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylpyridine-4-boronic acid | HCID 4192664 | — |
| Reactant | 1-[(6-Chloropyridin-3-yl)methyl]-4-(propan-2-yl)piperazine | HCID 43421784 | — |
| Product | 5-(4-Isopropylpiperazin-1-ylmethyl)-2'-methyl-[2,4']bipyridinyl, trihydrochloride | HCID 131730137 | — |
Reaction Steps
1-(6-Chloropyridin-3-ylmethyl)-4-isopropylpiperazine (0.2 g, 0.788 mmol) and 2-methylpyridin-4-boronic acid (0.119 g, 0.867 mmol) were mixed with catalyst and reacted in the same manner as in example 18. The title compound was isolated as yellow crystals of the trihydrochloride. Yield: 295 mg (73%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08344001B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-df55b194c1214e7ca136b92876f79dd9 |
| Source note | uspto-grants-2013_01 |