HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[(6-Chloropyridin-3-yl)methyl]-4-(propan-2-yl)piperazine → 4-[5-(4-Isopropylpiperazin-1-ylmethyl)pyridin-2-yl]-N,N-dimethylbenzenesulfonamide, trihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[(6-Chloropyridin-3-yl)methyl]-4-(propan-2-yl)piperazine | HCID 43421784 | — |
| Reactant | 4-(N,N-Dimethylsulphonamido)benzeneboronic acid | HCID 44119328 | — |
| Product | 4-[5-(4-Isopropylpiperazin-1-ylmethyl)pyridin-2-yl]-N,N-dimethylbenzenesulfonamide, trihydrochloride | HCID 131730138 | — |
Reaction Steps
1-(6-Chloropyridin-3-ylmethyl)-4-isopropylpiperazine (0.5 g, 1.97 mmol) and 4-(N,N-dimethylaminosulfonyl)phenylboronic acid (0.496 g, 2.2 mmol)) were mixed with catalyst and reacted in the same manner as in example 18. The title compound was isolated as white crystals of the trihydrochloride. Yield: 660 g (71%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08344001B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-3cb89b0f36104ff1830c969c608a4ac6 |
| Source note | uspto-grants-2013_01 |