Tetrahydrofuran → HCID 59543423, compound

Participants

Reaction Steps

4-[6-(4-Cyclobutylpiperazin-1-ylmethyl)pyridin-3-yl]benzonitrile (0.066 g, 0.2 mmol) was dissolved in DCM (1 mL) DIBAL 1M in THF (0.2 mL) was added. The reaction mixture was stirred at RT for 1 hour. LC-MS showed no product. Another 1.5 eq. of DIBAL (0.2 mL) was added and stirring continued 1 hour. LC-MS showed full conversion. The reaction mixture was stored at −20° C. for 3 days. The reaction mixture was added DCM (5 mL) and cold NH4Claq (5 mL). The DCM phase was washed with water (5 mL) and brine (5 mL), dried with MgSO4, filtered and evaporation afforded the title compound as the free base. 34.5 mg (51%).

Provenance & Evidence