Chlorosulfonic acid → HCID 58433497, compound

HRID 1798957Notes

Reaction equation

HRID 1798957 reaction equation
[Cl:1][C:2]1[C:3]([NH:12][CH2:13][C:14]2([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[Cl:26][S:27](O)(=[O:29])=[O:28]>C(Cl)Cl>[Cl:1][C:2]1[C:3]([NH:12][CH2:13][C:14]2([C:20]3[CH:25]=[CH:24][C:23]([S:27]([Cl:26])(=[O:29])=[O:28])=[CH:22][CH:21]=3)[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1

Participants

4

Reactant 2

HCID 24638Chlorosulfonic acidHCID 58433490HCID 58433490, compound

Product 1

HCID 58433497HCID 58433497, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

185 mg of (3-Chloro-5-trifluoromethyl-pyridin-2-yl)-(1-phenyl-cyclohexylmethyl)-amine were dissolved in 15 ml of methylenchloride and 0.14 ml of chlorosulfonic acid were added. The reaction mixture was stirred at room temperature for 4 days and than poured on ice water (20 ml). The organic layer was separated, washed twice with 50 ml of brine and then dried over MgSO4. The solvent was removed in vacuo to obtain 194 mg g of the crude product.

Workup

  1. additionthan poured on ice water (20 ml)
  2. customThe organic layer was separated
  3. washwashed twice with 50 ml of brine
  4. dry with materialdried over MgSO4
  5. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-d9707b838f96458a80063c53f79f016e
Source dataset
uspto-grants-2013_01
Patent number
US08344004B2

Reaction notes

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