Chlorosulfonic acid → Trans-4-(2-acetylamino-cyclopentyl)-benzenesulfonyl chloride

HRID 1798959노트

반응식

HRID 1798959 반응식
[C:1]1([CH:7]2[CH2:11][CH2:10][CH2:9][CH:8]2[NH:12][C:13](=[O:15])[CH3:14])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:16][S:17](O)(=[O:19])=[O:18]>ClCCl>[C:13]([NH:12][C@@H:8]1[CH2:9][CH2:10][CH2:11][C@H:7]1[C:1]1[CH:6]=[CH:5][C:4]([S:17]([Cl:16])(=[O:19])=[O:18])=[CH:3][CH:2]=1)(=[O:15])[CH3:14]

참가 물질

4

반응물 2

HCID 24638Chlorosulfonic acidHCID 66645957N-(2-Phenyl-cyclopentyl)-acetamide

생성물 1

HCID 58433496Trans-4-(2-acetylamino-cyclopentyl)-benzenesulfonyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

4.7 g of the crude product of example 2a were dissolved in 90 ml of dichloromethane. To this mixture 5.4 ml of chloro sulfonic acid were added drop by drop under stirring at room temperature. The reaction mixture was heated at 50° C. for 1 hour and, after cooling to room temperature, triturated with 70 ml of ice water. After separating the organic layer was dried over sodium sulfate and evaporated to dryness yielding 4.4 g of the crude product.

후처리

  1. temperatureThe reaction mixture was heated at 50° C. for 1 hour
  2. temperatureafter cooling to room temperature
  3. customtriturated with 70 ml of ice water
  4. customAfter separating the organic layer
  5. dry with materialwas dried over sodium sulfate
  6. customevaporated to dryness

출처 및 근거

ORD 기록
ord-dbdb4243f3164315bae13e61b12e70f7
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08344004B2

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