HCID 66997518, compound → HCID 66997561, compound

HRID 17990Notes

Reaction equation

HRID 17990 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:24]=[CH:25][C:26]=1[F:27])[CH2:5][N:6]1[CH2:15][CH2:14][C:13]2[C:8](=[C:9]([OH:22])[CH:10]=[N+:11]([O-])[C:12]=2[C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:7]1=[O:23]>C(OC(=O)C)(=O)C>[C:16]([O:18][C:10]1[N:11]=[C:12]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:13]2[CH2:14][CH2:15][N:6]([CH2:5][C:4]3[CH:24]=[CH:25][C:26]([F:27])=[C:2]([Cl:1])[CH:3]=3)[C:7](=[O:23])[C:8]=2[C:9]=1[O:22][C:9](=[O:22])[CH3:8])(=[O:17])[CH3:12]

Participants

3

Reactant 1

HCID 66997518HCID 66997518, compound

Product 1

HCID 66997561HCID 66997561, compound

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

A solution of ethyl 6-(3-chloro-4-fluorobenzyl)-4-hydroxy-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carboxylate 2-oxide (23 g, 58 mmol) in acetic anhydride (400 mL) was heated under nitrogen at 100° C. for one hour. The product mixture was concentrated under vacuum to the title bisacetate and was used in the following step without further purification.

Workup

  1. concentrationThe product mixture was concentrated under vacuum to the title bisacetate
  2. customwas used in the following step without further purification

Sources & evidence

ORD record
ord-2854a54fd2fc4c4fb7ea9ef8fbbb375b
Source dataset
uspto-grants-2010_06
Patent number
US07741315B2

Reaction notes

Loading…