1,4-Dioxane hydrochloride → N,N-dimethylazetidine-3-carboxamide hydrochloride

A mixture of t-butyl 3-dimethylcarbamoyl-azetidine-1-carboxylate (0.365 g) and 4N hydrogen chloride/dioxane solution (5 ml) was stirred at room temperature for 5 hr 15 min. The reaction mixture was concentrated under reduced pressure, dioxane was added to the obtained residue and the mixture was concentrated again under reduced pressure. The obtained residue was dried under reduced pressure at 60° C. to give the title compound (0.290 g). The obtained residue was directly used for the next reaction without further purification.

1. concentrationThe reaction mixture was concentrated under reduced pressure, dioxane
2. additionwas added to the obtained residue
3. concentrationthe mixture was concentrated again under reduced pressure
4. customThe obtained residue was dried under reduced pressure at 60° C.

ORD record

ord-3952b8cd197842188963e54652bc2976

Source dataset

uspto-grants-2013_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08343994B2