HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → Methyl 2-(2-nitrophenyl)thiazolo[5,4-b]pyridine-6-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Phosphorus sulfide (P2S5) | HCID 14817 | — |
| Reactant | HCID 58551882 | HCID 58551882 | — |
| Solvent | P-Xylene | HCID 7809 | — |
| Product | Methyl 2-(2-nitrophenyl)thiazolo[5,4-b]pyridine-6-carboxylate | HCID 58551887 | 57% |
Reaction Conditions
| Temperature | 130 °C |
|---|
Reaction Steps
A mixture of methyl 6-chloro-5-(2-nitrobenzamido)nicotinate (1 eq), P2S5 (2.1 eq), and pyridine (7.6 eq) in p-xylene was heated at 130° C. for 2 h. The clear liquid was decanted and allowed to cool to room temperature. The resultant precipitate was collected by filtration and dried to give methyl 2-(2-nitrophenyl)thiazolo[5,4-b]pyridine-6-carboxylate (57% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08343997B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-2aec5ce4bd534a61a681851856f038df |
| Source note | uspto-grants-2013_01 |