tert-Butyl piperazine-1-carboxylate → HCID 58551892, compound

HRID 1799107Notes

Reaction equation

HRID 1799107 reaction equation
C(OC(N1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2S[C:18]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:17][C:16]=2[C:26]([OH:28])=[O:27])[CH2:10][CH2:9]1)=O)(C)(C)C.N1(C(OC(C)(C)C)=[O:36])CCNCC1>>[C:20]1([C:18]2[O:36][C:15]([CH2:14][N:11]3[CH2:12][CH2:13][CH2:9][CH2:10]3)=[C:16]([C:26]([OH:28])=[O:27])[N:17]=2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 67425121HCID 67425121, compound

Product 1

HCID 58551892HCID 58551892, compoundYield 38%

Procedure

The title compound was prepared by the procedure described for 5-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)-2-phenylthiazole-4-carboxylic acid substituting pyrrolidine for t-butyl piperazine-1-carboxylate in 38% yield.

Sources & evidence

ORD record
ord-48612daecae448fabd78f273cc5175d9
Source dataset
uspto-grants-2013_01
Patent number
US08343997B2

Reaction notes

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