2-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acid → N-(2-(6-((4-(2-methoxyethyl)piperazin-1-yl)methyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-phenyl-5-(trifluoromethyl)oxazole-4-carboxamide

Participants

Reaction Steps

The title compound was prepared according to amide synthesis general method B, utilizing 2-(6-((4-(2-methoxyethyl)piperazin-1-yl)methyl)thiazolo[5,4-b]pyridin-2-yl)aniline and 2-phenyl-5-(trifluoromethyl)oxazole-4-carboxylic acid (1.5 eq). The product was filtered from the crude reaction mixture, evaporated with methanol, and purified by silica gel chromatography (gradient 0 to 10% methanol in CH2Cl2) and by prep HPLC. MS Calcd for C31H29F3N6O3S: 622.20. Found (M+H)+ m/z=623.

Provenance & Evidence