HCID 86646668, compound → HCID 66725145, compound

Participants

Reaction Steps

Two-hundred (200) mg of methyl (3R)-3-(3-amino-4-chlorophenyl)-4-(2,2,2-trifluoroacetylamino)butanoate (65b) was dissolved in 2.5 mL of methanol and 0.2 mL of 2N sodium hydroxide, the reaction mixture was stirred at room temperature for 16 hours, the solvent was removed under reduced pressure, and the residue purified by preparative HPLC to provide 90 mg of the title compound (65c). 1H NMR (400 MHz, CD3OD): δ 7.21 (d, J=8.0 Hz, 1H), 6.83 (s, 1H), 6.65 (d, J=8.0 Hz, 1H), 3.30-3.26 (m, 2H), 3.15-3.11 (m, 1H), 2.74 (dd, J=16.4, 6.4 Hz, 1H), 2.62 (dd, J=16.4, 6.4 Hz, 1H); MS (ESI) m/z 229.0 (M+H)+.

Provenance & Evidence