Acetic Anhydride → HCID 57972163, compound

Participants

Reaction Steps

Acetic anhydride (50 μL, 0.526 mmol) and N-ethyl-N,N-diisopropylamine (84 μL, 0.479 mmol) were added to a methylene chloride:THF (1:1, V/V, 4 mL) solution of 4-(2-cyclopropylethoxy)-N-{2-[(2-hydroxyethyl)amino]-2-oxo-1-[4-(trifluoromethoxy)benzyl]ethyl}benzamide (116 mg, 0.239 mmol) prepared in Example 4. The mixture was stirred at room temperature for 65 hours. The reaction solution was evaporated, and the residue was purified by thin layer chromatography for separation (ethyl acetate, developed once) to give 65 mg of the title compound (white powder, yield: 52%).

Provenance & Evidence