HRID1799241

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCCc1ccc(CC(NC(=O)c2ccc(OCCC3CC3)cc2)C(=O)NCCO)cc1

HCID57972150

未命名化合物

结构：O=C(NCCCO)/C(=C/c1ccc(OC(F)(F)F)cc1)NC(=O)c1ccc(OCCC2CC2)cc1

HCID69019224

未命名化合物

PRODUCTS

生成物

结构：O=C(NC(Cc1ccc(OC(F)(F)F)cc1)C(=O)NCCCO)c1ccc(OCCC2CC2)cc1

HCID57972140

未命名化合物

收率 85.4%

PROCEDURE

实验过程

A reaction similar to that described in Example (1 (1e) was conducted using 4-(2-cyclopropylethoxy)-N-{(Z)-1-{[(3-hydroxypropyl)amino]carbonyl}-2-[4-(trifluoromethoxy)phenyl]vinyl}benzamide (197 mg) to give 169 mg of the title compound (white powder).

WORKUP

后处理

customA reaction similar to

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e2ba8ec69a284bf08f1af2f304238907
来源数据集: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08344029B2
来源说明: uspto-grants-2013_01

反应 SMILES

C1(CCOC2C=CC(C(NC(CC3C=CC(CCC)=CC=3)C(NCCO)=O)=O)=CC=2)CC1.[CH:33]1([CH2:36][CH2:37][O:38][C:39]2[CH:67]=[CH:66][C:42]([C:43]([NH:45]/[C:46](/[C:59]([NH:61][CH2:62][CH2:63][CH2:64][OH:65])=[O:60])=[CH:47]\[C:48]3[CH:53]=[CH:52][C:51]([O:54][C:55]([F:58])([F:57])[F:56])=[CH:50][CH:49]=3)=[O:44])=[CH:41][CH:40]=2)[CH2:35][CH2:34]1>>[CH:33]1([CH2:36][CH2:37][O:38][C:39]2[CH:67]=[CH:66][C:42]([C:43]([NH:45][CH:46]([CH2:47][C:48]3[CH:49]=[CH:50][C:51]([O:54][C:55]([F:58])([F:57])[F:56])=[CH:52][CH:53]=3)[C:59]([NH:61][CH2:62][CH2:63][CH2:64][OH:65])=[O:60])=[O:44])=[CH:41][CH:40]=2)[CH2:34][CH2:35]1