4-(2-Cyclopropylethoxy)-n-[2-[(2-hydroxyethyl)amino]-2-oxo-1-(4-propylbenzyl)ethyl]benzamide → 4-(Cyclopropylmethoxy)-n-{1-(4-ethoxybenzyl)-2-[(2-hydroxyethyl)amino]-2-oxoethyl}benzamide

HRID 1799249Notes

Reaction equation

HRID 1799249 reaction equation
C1(CCOC2C=CC(C(NC(CC3C=CC(CCC)=CC=3)C(NCCO)=O)=O)=CC=2)CC1.[CH:33]1([CH2:36][O:37][C:38]2[CH:63]=[CH:62][C:41]([C:42]([NH:44]/[C:45](/[C:56]([NH:58][CH2:59][CH2:60][OH:61])=[O:57])=[CH:46]\[C:47]3[CH:52]=[CH:51][C:50]([O:53][CH2:54][CH3:55])=[CH:49][CH:48]=3)=[O:43])=[CH:40][CH:39]=2)[CH2:35][CH2:34]1>>[CH:33]1([CH2:36][O:37][C:38]2[CH:63]=[CH:62][C:41]([C:42]([NH:44][CH:45]([CH2:46][C:47]3[CH:48]=[CH:49][C:50]([O:53][CH2:54][CH3:55])=[CH:51][CH:52]=3)[C:56]([NH:58][CH2:59][CH2:60][OH:61])=[O:57])=[O:43])=[CH:40][CH:39]=2)[CH2:35][CH2:34]1

Participants

3

Reactant 2

HCID 579721504-(2-Cyclopropylethoxy)-n-[2-[(2-hydroxyethyl)amino]-2-oxo-1-(4-propylbenzyl)ethyl]benzamideHCID 690179624-(Cyclopropylmethoxy)-n-((z)-2-(4-ethoxyphenyl)-1-{[(2-hydroxyethyl)amino]carbonyl}vinyl)benzamide

Product 1

HCID 579720854-(Cyclopropylmethoxy)-n-{1-(4-ethoxybenzyl)-2-[(2-hydroxyethyl)amino]-2-oxoethyl}benzamideYield 16%

Procedure

A reaction similar to that described in Example (1 (1e) was conducted using 4-(cyclopropylmethoxy)-N-((Z)-2-(4-ethoxyphenyl)-1-{[(2-hydroxyethyl)amino]carbonyl}vinyl)benzamide (255 mg) to give 41 mg of the title compound (white powder).

Workup

  1. customA reaction similar to

Sources & evidence

ORD record
ord-d46569aa1804491788557ac51a2b2b16
Source dataset
uspto-grants-2013_01
Patent number
US08344029B2

Reaction notes

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