4-Oxazolin-2-one → 4-(cyclopropylmethoxy)-N-((Z)-2-(4-cyclopropylphenyl)-1-{[(2-hydroxyethyl)amino]carbonyl}vinyl)benzamide

Participants

Reaction Steps

A reaction similar to that described in Example 1 (1c) was conducted using N-[4-(cyclopropylmethoxy)benzoyl]glycine (299 mg) prepared in Example 18 (18b) and 4-cyclopropylbenzaldehyde (184 mg) to give the corresponding oxazolone (366 mg). A reaction similar to that described in Example (1 (1d) was conducted using all this oxazolone to give 385 mg of 4-(cyclopropylmethoxy)-N-((Z)-2-(4-cyclopropylphenyl)-1-{[(2-hydroxyethyl)amino]carbonyl}vinyl)benzamide (white powder).

Provenance & Evidence