4-(2-Cyclopropylethoxy)-n-[2-[(2-hydroxyethyl)amino]-2-oxo-1-(4-propylbenzyl)ethyl]benzamide → HCID 16041205, compound

HRID 1799255Notes

Reaction equation

HRID 1799255 reaction equation
C1(CCOC2C=CC(C(NC(CC3C=CC(CCC)=CC=3)C(NCCO)=O)=O)=CC=2)CC1.[F:33][CH:34]([F:65])[CH2:35][O:36][C:37]1[CH:64]=[CH:63][C:40]([C:41]([NH:43]/[C:44](/[C:57]([NH:59][CH2:60][CH2:61][OH:62])=[O:58])=[CH:45]\[C:46]2[CH:51]=[CH:50][C:49]([O:52][C:53]([F:56])([F:55])[F:54])=[CH:48][CH:47]=2)=[O:42])=[CH:39][CH:38]=1>>[F:65][CH:34]([F:33])[CH2:35][O:36][C:37]1[CH:64]=[CH:63][C:40]([C:41]([NH:43][CH:44]([CH2:45][C:46]2[CH:51]=[CH:50][C:49]([O:52][C:53]([F:54])([F:55])[F:56])=[CH:48][CH:47]=2)[C:57]([NH:59][CH2:60][CH2:61][OH:62])=[O:58])=[O:42])=[CH:39][CH:38]=1

Participants

3

Reactant 2

HCID 579721504-(2-Cyclopropylethoxy)-n-[2-[(2-hydroxyethyl)amino]-2-oxo-1-(4-propylbenzyl)ethyl]benzamideHCID 87658293HCID 87658293, compound

Product 1

HCID 16041205HCID 16041205, compoundYield 73.4%

Procedure

A reaction similar to that described in Example (1 (1e) was conducted using 4-(2,2-difluoroethoxy)-N-{(Z)-1-{[(2-hydroxyethyl)amino]carbonyl}-2-[4-(trifluoromethoxy)phenyl]vinyl}benzamide (190 mg) to give 140 mg of the title compound (white powder).

Workup

  1. customA reaction similar to

Sources & evidence

ORD record
ord-1dc91c9e1d9741fcb0fb009eae913e24
Source dataset
uspto-grants-2013_01
Patent number
US08344029B2

Reaction notes

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