4-(2-Cyclopropylethoxy)-n-[2-[(2-hydroxyethyl)amino]-2-oxo-1-(4-propylbenzyl)ethyl]benzamide → HCID 57972106, compound

HRID 1799259Notes

Reaction equation

HRID 1799259 reaction equation
C1(CCOC2C=CC(C(NC(CC3C=CC(CCC)=CC=3)C(NCCO)=O)=O)=CC=2)CC1.[F:33][CH:34]([F:66])[O:35][C:36]1[CH:41]=[CH:40][C:39](/[CH:42]=[C:43](\[NH:50][C:51](=[O:65])[C:52]2[CH:57]=[CH:56][C:55]([O:58][CH2:59][CH2:60][C:61]([F:64])([F:63])[F:62])=[CH:54][CH:53]=2)/[C:44]([NH:46][CH2:47][CH2:48][OH:49])=[O:45])=[CH:38][CH:37]=1>>[F:66][CH:34]([F:33])[O:35][C:36]1[CH:41]=[CH:40][C:39]([CH2:42][CH:43]([NH:50][C:51](=[O:65])[C:52]2[CH:57]=[CH:56][C:55]([O:58][CH2:59][CH2:60][C:61]([F:62])([F:63])[F:64])=[CH:54][CH:53]=2)[C:44]([NH:46][CH2:47][CH2:48][OH:49])=[O:45])=[CH:38][CH:37]=1

Participants

3

Reactant 2

HCID 579721504-(2-Cyclopropylethoxy)-n-[2-[(2-hydroxyethyl)amino]-2-oxo-1-(4-propylbenzyl)ethyl]benzamideHCID 69020717HCID 69020717, compound

Product 1

HCID 57972106HCID 57972106, compoundYield 68.3%

Procedure

A reaction similar to that described in Example (1 (1e) was conducted using N-((Z)-2-[4-(difluoromethoxy)phenyl]-1-{[(2-hydroxyethyl)amino]carbonyl}vinyl)-4-(3,3,3-trifluoropropoxy)benzamide (204 mg) to give 140 mg of the title compound (white powder).

Workup

  1. customA reaction similar to

Sources & evidence

ORD record
ord-b636fb85ab474f25a9651319c733d9b1
Source dataset
uspto-grants-2013_01
Patent number
US08344029B2

Reaction notes

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