4-(2-Cyclopropylethoxy)-n-[2-[(2-hydroxyethyl)amino]-2-oxo-1-(4-propylbenzyl)ethyl]benzamide → HCID 57972098, compound

HRID 1799264Notes

Reaction equation

HRID 1799264 reaction equation
C1(CCOC2C=CC(C(NC(CC3C=CC(CCC)=CC=3)C(NCCO)=O)=O)=CC=2)CC1.[OH:33][CH2:34][CH2:35][NH:36][C:37](/[C:39](/[NH:51][C:52](=[O:70])[C:53]1[CH:58]=[CH:57][C:56]([O:59][C:60]2[CH:65]=[CH:64][C:63]([C:66]([F:69])([F:68])[F:67])=[CH:62][CH:61]=2)=[CH:55][CH:54]=1)=[CH:40]/[C:41]1[CH:46]=[CH:45][C:44]([C:47]([F:50])([F:49])[F:48])=[CH:43][CH:42]=1)=[O:38]>>[OH:33][CH2:34][CH2:35][NH:36][C:37](=[O:38])[CH:39]([NH:51][C:52](=[O:70])[C:53]1[CH:58]=[CH:57][C:56]([O:59][C:60]2[CH:61]=[CH:62][C:63]([C:66]([F:67])([F:68])[F:69])=[CH:64][CH:65]=2)=[CH:55][CH:54]=1)[CH2:40][C:41]1[CH:42]=[CH:43][C:44]([C:47]([F:50])([F:49])[F:48])=[CH:45][CH:46]=1

Participants

3

Reactant 2

HCID 579721504-(2-Cyclopropylethoxy)-n-[2-[(2-hydroxyethyl)amino]-2-oxo-1-(4-propylbenzyl)ethyl]benzamideHCID 87164886HCID 87164886, compound

Product 1

HCID 57972098HCID 57972098, compoundYield 89.2%

Procedure

A reaction similar to that described in Example (1 (1e) was conducted using N-{(Z)-1-{[(2-hydroxyethyl)amino]carbonyl}-2-[4-(trifluoromethyl)phenyl]vinyl}-4-[4-(trifluoromethyl)phenoxy]benzamide (172 mg) to give 154 mg of the title compound (white powder).

Workup

  1. customA reaction similar to

Sources & evidence

ORD record
ord-9e7e0287a6954fe6b7800a0a6672576b
Source dataset
uspto-grants-2013_01
Patent number
US08344029B2

Reaction notes

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