Ethanolamine → HCID 57972125, compound

HRID 1799265Notes

Reaction equation

HRID 1799265 reaction equation
[Cl:1][C:2]1[CH:33]=[CH:32][C:5]([O:6][C:7]2[CH:31]=[CH:30][C:10]([C:11]([NH:13][CH:14]([CH2:18][C:19]3[CH:24]=[CH:23][C:22]([O:25][C:26]([F:29])([F:28])[F:27])=[CH:21][CH:20]=3)[C:15]([OH:17])=O)=[O:12])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[NH2:34][CH2:35][CH2:36][OH:37]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][C:7]2[CH:31]=[CH:30][C:10]([C:11]([NH:13][CH:14]([CH2:18][C:19]3[CH:20]=[CH:21][C:22]([O:25][C:26]([F:27])([F:29])[F:28])=[CH:23][CH:24]=3)[C:15]([NH:34][CH2:35][CH2:36][OH:37])=[O:17])=[O:12])=[CH:9][CH:8]=2)=[CH:32][CH:33]=1

Participants

3

Reactant 2

HCID 700EthanolamineHCID 69018610HCID 69018610, compound

Product 1

HCID 57972125HCID 57972125, compoundYield 83%

Procedure

A reaction similar to that described in Example 32 (32c) was conducted using 2-{[4-(4-chlorophenoxy)benzoyl]amino}-3-[4-(trifluoromethoxy)phenyl]propanoic acid (467 mg, 0.973 mmol) prepared in Example 48 (48a) and 2-aminoethanol (106 μL, 1.75 mmol) to give 420 mg of the title compound (white powder, yield: 83%).

Workup

  1. customA reaction similar to

Sources & evidence

ORD record
ord-513924442f7944de83020f7881d4a30b
Source dataset
uspto-grants-2013_01
Patent number
US08344029B2

Reaction notes

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