Ethanolamine → HCID 57972094, compound

HRID 1799266Notes

Reaction equation

HRID 1799266 reaction equation
[CH3:1][O:2][C:3]1[CH:34]=[CH:33][C:6]([O:7][C:8]2[CH:32]=[CH:31][C:11]([C:12]([NH:14][CH:15]([CH2:19][C:20]3[CH:25]=[CH:24][C:23]([O:26][C:27]([F:30])([F:29])[F:28])=[CH:22][CH:21]=3)[C:16]([OH:18])=O)=[O:13])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1.[NH2:35][CH2:36][CH2:37][OH:38]>>[OH:38][CH2:37][CH2:36][NH:35][C:16](=[O:18])[CH:15]([NH:14][C:12](=[O:13])[C:11]1[CH:31]=[CH:32][C:8]([O:7][C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:34][CH:33]=2)=[CH:9][CH:10]=1)[CH2:19][C:20]1[CH:25]=[CH:24][C:23]([O:26][C:27]([F:29])([F:30])[F:28])=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 700EthanolamineHCID 69017420HCID 69017420, compound

Product 1

HCID 57972094HCID 57972094, compoundYield 89.3%

Procedure

A reaction similar to that described in Example 32 (32c) was conducted using 2-{[4-(4-methoxyphenoxy)benzoyl]amino}-3-[4-(trifluoromethoxy)phenyl]propanoic acid (490 mg, 1.03 mmol) prepared in Example 49 (49a) and 2-aminoethanol (112 μL, 1.86 mmol) to give 477 mg of the title compound (white powder, yield: 89%).

Workup

  1. customA reaction similar to

Sources & evidence

ORD record
ord-ca26b74153fa485dbc9ba91d9fdf6ad0
Source dataset
uspto-grants-2013_01
Patent number
US08344029B2

Reaction notes

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