HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3,3,3-Trifluoropropoxy)benzoic acid → 2-[((2S)-3-[4-(Trifluoromethoxy)phenyl]-2-{[4-(3,3,3-trifluoropropoxy)benzoyl]amino}propanoyl)amino]ethyl acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3,3,3-Trifluoropropoxy)benzoic acid | HCID 58111655 | — |
| Reactant | 2-({(2S)-2-amino-3-[4-(trifluoromethoxy)phenyl]propanoyl}amino)ethyl acetate | HCID 69017543 | — |
| Product | 2-[((2S)-3-[4-(Trifluoromethoxy)phenyl]-2-{[4-(3,3,3-trifluoropropoxy)benzoyl]amino}propanoyl)amino]ethyl acetate | HCID 86636528 | — |
Reaction Steps
A reaction similar to that described in Example 50 was conducted using 2-({(2S)-2-amino-3-[4-(trifluoromethoxy)phenyl]propanoyl}amino)ethyl acetate and 4-(3,3,3-trifluoropropoxy)benzoic acid obtained in the preparation process of Example 33 (33a) to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08344029B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-51dd829be42c434d97bbd61c8335b8b7 |
| Source note | uspto-grants-2013_01 |