4-(3,3,3-Trifluoropropoxy)benzoic acid → 2-[((2S)-3-[4-(Trifluoromethyl)phenyl]-2-{[4-(3,3,3-trifluoropropoxy)benzoyl]amino}propanoyl)amino]ethyl acetate

HRID 1799273Notes

Reaction equation

HRID 1799273 reaction equation
[C:1]([O:4][CH2:5][CH2:6][NH:7][C:8](=[O:22])[C@@H:9]([NH2:21])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=1)(=[O:3])[CH3:2].[F:23][C:24]([F:38])([F:37])[CH2:25][CH2:26][O:27][C:28]1[CH:36]=[CH:35][C:31]([C:32](O)=[O:33])=[CH:30][CH:29]=1>>[C:1]([O:4][CH2:5][CH2:6][NH:7][C:8](=[O:22])[C@@H:9]([NH:21][C:32](=[O:33])[C:31]1[CH:35]=[CH:36][C:28]([O:27][CH2:26][CH2:25][C:24]([F:38])([F:37])[F:23])=[CH:29][CH:30]=1)[CH2:10][C:11]1[CH:12]=[CH:13][C:14]([C:17]([F:19])([F:20])[F:18])=[CH:15][CH:16]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 581116554-(3,3,3-Trifluoropropoxy)benzoic acidHCID 690178742-({(2S)-2-amino-3-[4-(trifluoromethyl)phenyl]propanoyl}amino)ethyl acetate

Product 1

HCID 579720882-[((2S)-3-[4-(Trifluoromethyl)phenyl]-2-{[4-(3,3,3-trifluoropropoxy)benzoyl]amino}propanoyl)amino]ethyl acetate

Procedure

A reaction similar to that described in Example 50 was conducted using 2-({(2S)-2-amino-3-[4-(trifluoromethyl)phenyl]propanoyl}amino)ethyl acetate and 4-(3,3,3-trifluoropropoxy)benzoic acid obtained in the preparation process of Example 33 (33a) to give the title compound.

Workup

  1. customA reaction similar to

Sources & evidence

ORD record
ord-3df547381d174fab9be7c2328bf24cf9
Source dataset
uspto-grants-2013_01
Patent number
US08344029B2

Reaction notes

Loading…