HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → N-{2-Amino-2-oxo-1-[4-(trifluoromethoxy)benzyl]ethyl}-4-(3,3,3-trifluoropropoxy)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3-[4-(Trifluoromethoxy)phenyl]-2-{[4-(3,3,3-trifluoropropoxy)benzoyl]amino}propanoic acid | HCID 78068623 | — |
| Product | N-{2-Amino-2-oxo-1-[4-(trifluoromethoxy)benzyl]ethyl}-4-(3,3,3-trifluoropropoxy)benzamide | HCID 57972152 | — |
Reaction Steps
A reaction similar to that described in Example 32 (32c) was conducted using 3-[4-(trifluoromethoxy)phenyl]-2-{[4-(3,3,3-trifluoropropoxy)benzoyl]amino}propanoic acid (5.00 g) prepared in Example 70 (70a) and ammonia (16.1 mL, 2 M ethanol solution) to give 4.51 g of the title compound (white powder).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08344029B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-c9c6085cd3064732b380c37779ec2ad2 |
| Source note | uspto-grants-2013_01 |