Ammonia → N-{2-Amino-2-oxo-1-[4-(trifluoromethoxy)benzyl]ethyl}-4-(4,4,4-trifluorobutoxy)benzamide

HRID 1799287Notes

Reaction equation

HRID 1799287 reaction equation
[F:1][C:2]([F:33])([F:32])[CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:31]=[CH:30][C:10]([C:11]([NH:13][CH:14]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][C:26]([F:29])([F:28])[F:27])=[CH:21][CH:20]=2)[C:15](O)=[O:16])=[O:12])=[CH:9][CH:8]=1.[NH3:34]>>[NH2:34][C:15](=[O:16])[CH:14]([NH:13][C:11](=[O:12])[C:10]1[CH:30]=[CH:31][C:7]([O:6][CH2:5][CH2:4][CH2:3][C:2]([F:33])([F:32])[F:1])=[CH:8][CH:9]=1)[CH2:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][C:26]([F:29])([F:28])[F:27])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 780686222-{[4-(4,4,4-Trifluorobutoxy)benzoyl]amino}-3-[4-(trifluoromethoxy)phenyl]propanoic acid

Product 1

HCID 57972135N-{2-Amino-2-oxo-1-[4-(trifluoromethoxy)benzyl]ethyl}-4-(4,4,4-trifluorobutoxy)benzamide

Procedure

A reaction similar to that described in Example 32 (32c) was conducted using 2-{[4-(4,4,4-trifluorobutoxy)benzoyl]amino}-3-[4-(trifluoromethoxy)phenyl]propanoic acid (360 mg) prepared in Example 82 (82a) and ammonia (600 μL, 2 M methanol solution) to give 122 mg of the title compound (white powder).

Workup

  1. customA reaction similar to

Sources & evidence

ORD record
ord-82b2f581a1d040de8638ff9e4374126c
Source dataset
uspto-grants-2013_01
Patent number
US08344029B2

Reaction notes

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